De Kalb County Alabama has 13 places on the National Register of Historic Places including 3 places of Statewide significance. Significant places include Alabama Great Southern Railroad Passenger Depot, Fort Payne Opera House and Mentone Springs Hotel, Alabama Builder's Hardware Manufacturing Company Complex (Boundary Increase) and Alabama Builders' Hardware Manufacturing Company.
The famous person Charles Gideon Kershaw is associated with one of more of the De Kalb County historic places.
Some of the country's most noteable architects helped create the De Kalb County places including Charles C. Taylor, Sirrine,J.E. and & Co.. Prominent architectural styles found in De Kalb Country are Colonial Revival, Late Victorian and Queen Anne.