Prehistoric cultural affiliation(s) include Orr Phase, Correctionville-Blue Earth, Mill Creek, Native American and Middle Missouri dating back to 5999 BC.
The famous person Robert A. Lewis is associated with one of more of the Cherokee County historic places.
Some of the country's most noteable architects helped create the Cherokee County places including Illinois Central Railroad, King, George E., Bridge Co., King Iron Bridge & Mfg. Co., Josselyn and Taylor, Warren Wilfred Beach, Robert A. Lewis, F.E. Wetherell and Beuttler and Arnold. Prominent architectural styles found in Cherokee Country are Late Victorian, Classical Revival and Late 19th And 20th Century Revivals.