The famous person James Reynolds is associated with one of more of the Cape Girardeau County historic places.
Some of the country's most noteable architects helped create the Cape Girardeau County places including Joseph Lansmon, Walter P. Manske, Harold Roth, P.A. Smith, Julius Vasterling, Henry Ossenkop, Edwin Branch Deane, William Regenhardt, Bernard Wooner and George P. et al Bartling. Prominent architectural styles found in Cape Girardeau Country are Italianate, Late 19th And 20th Century Revivals and Mission/Spanish Revival.