Pemiscot County Missouri has 7 places on the National Register of Historic Places including 1 place of National significance and 4 places of Statewide significance. Significant places include Campbell Archeological Site, Delta Center Mound, Denton Mound and Village Archeological Site, Murphy Mound Archeological Site and Wallace, J. M., Archeological Site.
Prehistoric cultural affiliation(s) include Middle Baytown, Early Baytown, Nodena Phase, Desoto and Middle Mississippian dating back to 500.
Some of the country's most noteable architects helped create the Pemiscot County places including George C. Morgan and District 111-Farm Security Admin.. Prominent architectural styles found in Pemiscot Country are .