Clay County Mississippi (Historic Districts) has 12 places on the National Register of Historic Places including 1 place of Statewide significance. Significant places include Brogan Mound and Village Site Discontiguous District, Brandtown Gin Historic District, Clay County Agricultural High School, Commerce Street Historic District and Court Street Historic District.
Prehistoric cultural affiliation(s) include Middle Woodland, Late Woodland and Mississippian dating back to 499 BC. Prominent architectural styles found in Clay Country are Bungalow/Craftsman, Queen Anne and Classical Revival.