Greenup County Kentucky (Historic Districts) has 4 places on the National Register of Historic Places including 1 place of National significance. Significant places include Lower Shawneetown Archeological District, Front Street District, South Greenup District, West Main Street District.
Prehistoric cultural affiliation(s) include Late Woodland, Middle Woodland and Historic Indian dating back to 499 BC. Prominent architectural styles found in Greenup Country are Queen Anne and Stick/Eastlake.