Lewis County Kentucky has 6 places on the National Register of Historic Places including 1 place of National significance and 3 places of Statewide significance. Significant places include Lower Shawneetown Archeological District, Cabin Creek Covered Bridge, Ohio River Lock and Dam No. 31 Grounds and Buildings and Stone Cellar on Cabin Creek and Union Monument in Vanceburg.
Prehistoric cultural affiliation(s) include Late Woodland, Middle Woodland and Historic Indian dating back to 499 BC. Prominent architectural styles found in Lewis Country are Bungalow/Craftsman and Classical Revival.