Piscataquis County Maine (Historic Districts) has 7 places on the National Register of Historic Places including 2 places of National significance and 2 places of Statewide significance. Significant places include Munsungan-Chase Lake Thoroughfare Archeological District, Sebec--Piscataquis River Confluence Prehistoric Archeological District, Chesuncook Village and Tramway Historic District and Burgess, Walter and Eva, Farm.
Prehistoric cultural affiliation(s) include Early,Middle, & Late Archaic, Ceramic, Paleo-Indian, Woodland and Late Pleistocene dating back to 10999 BC.
Some of the country's most noteable architects helped create the Piscataquis County places including C.B. Brann, F.E. Sands and Coombs and Gibbs. Prominent architectural styles found in Piscataquis Country are Late Victorian, Modern Movement and Queen Anne.