Pike County Missouri (Historic Districts) has 5 places on the National Register of Historic Places including 1 place of National significance. Significant places include Lock and Dam No. 24 Historic District, Clarksville Historic District, Georgia Street Historic District, Griffith--McCune Farmstead Historic District and North Third Street Historic District.
Some of the country's most noteable architects helped create the Pike County places including Overton Broadhead McCardie and Powhatan Baird. Prominent architectural styles found in Pike Country are Greek Revival, Italianate and Late 19th And 20th Century Revivals.