Marlboro County South Carolina has 12 places on the National Register of Historic Places including 1 place of National significance and 3 places of Statewide significance. Significant places include Manship Farmstead, Clio Historic District, Pegues Place and Robertson-Easterling-McLaurin House and Appin.
Several famous people are associated with these Marlboro County historic places including Claudius Pegues, John B. McLaurin, Charles Spencer McCall and Chancellor William Johnson. Prominent architectural styles found in Marlboro Country are Classical Revival, Italianate and Queen Anne.