De Witt County Texas (Historic Districts) has 5 places on the National Register of Historic Places including 3 places of Statewide significance. Significant places include Cuero Commercial Historic District, Cuero I Archeological District and Terrell--Reuss Streets Historic District, City Water Works and East Main Street Residential Historic District.
Prehistoric cultural affiliation(s) include Late Paleo and Spanish dating back to 1000.
Some of the country's most noteable architects helped create the De Witt County places including Jules Leffland and Valentine Hoch. Prominent architectural styles found in De Witt Country are Bungalow/Craftsman, Classical Revival and Greek Revival.