Sharkey County Mississippi has 5 places on the National Register of Historic Places including 1 place of National significance and 5 places of Statewide significance. Significant places include Rolling Fork Mounds, Cary Site (22Sh507), Leist A Site (22Sh520;22N1), Rolling Fork Mounds and Savory Site (22-Sh-518).
Prehistoric cultural affiliation(s) include Mississippian, Woodland, Marksville, Poverty Point Culture, Jakestown Phase, Middle Woodland/Issaquena and Late Woodland/Deasonville dating back to 1999 BC. Prominent architectural styles found in Sharkey Country are .