Prehistoric cultural affiliation(s) include Fort Ancient, Late Woodland, Middle Woodland, Historic Indian and Hopewell dating back to 499 BC.
Several famous people are associated with these Greenup County historic places including Jesse Stuart, John C. Kouns, Col. William Worthington and John McConnell.
Some of the country's most noteable architects helped create the Greenup County places including King Bridge Co., Chesapeake and Ohio Railroad and Robinson and Steinman. Prominent architectural styles found in Greenup Country are Greek Revival, Italianate and Stick/Eastlake.