Calhoun County Illinois has 6 places on the National Register of Historic Places including 1 place of National significance and 1 place of Statewide significance. Significant places include Kamp Mound Site and Golden Eagle-Toppmeyer Site, Brussels Historic District, Kamp Store and Klunk, Michael, Farmstead.
Prehistoric cultural affiliation(s) include Middle Woodland Hopewell, Late Woodland, Il Valley Hopewellian, Early Woodland and Mississippian dating back to 499 BC. Prominent architectural styles found in Calhoun Country are Early Commercial, Late Victorian and Mid 19th Century Revival.