Butler County Missouri (Historic Districts) has 5 places on the National Register of Historic Places including 1 place of National significance. Significant places include Little Black River Archeological District, Poplar Bluff Commercial Historic District, South Sixth Street Historic District.
Prehistoric cultural affiliation(s) include Middle Mississippian, Archaic and Et Al dating back to 500. Prominent architectural styles found in Butler Country are Colonial Revival, Italianate and Late 19th And 20th Century Revivals.