Pettis County Missouri (Historic Districts) has 14 places on the National Register of Historic Places including 1 place of Statewide significance. Significant places include Missouri State Fairgrounds Historic District, Bois d'Arc Cooperative Dairy Farm Historic District, Hillview Cooperative Dairy Farm Historic District, Osage Farms Unit No. 1 Historic District and Osage Farms Unit No. 25 Historic District.
Some of the country's most noteable architects helped create the Pettis County places including Thomas W. Bast, Farm Security Administration, Resettlement Administration, Boller Bros. and F.E. Hoffman. Prominent architectural styles found in Pettis Country are Art Deco, Italianate and Romanesque.