Greene County Missouri (Historic Districts) has 20 places on the National Register of Historic Places including 1 place of National significance and 2 places of Statewide significance. Significant places include Wilson's Creek National Battlefield (Boundary Increase), Pearson Creek Archeological District and Wilson's Creek National Battlefield (Boundary Increase), Campbell Avenue Historic District and Campbell Avenue Historic District (Boundary Increase I).
Prehistoric cultural affiliation(s) include Marginal Mississippi, Woodland and Early/Middle/Late Archaic dating back to 8999 BC.
Some of the country's most noteable architects helped create the Greene County places including Frank Hunt, Ed Waddell, Johnson Construction Co., Opal and Torbitt, L.P. Larsen, Mac MacCandless and Carl Boller. Prominent architectural styles found in Greene Country are Italianate, Colonial Revival and Bungalow/Craftsman.