Chickasaw County Mississippi has 10 places on the National Register of Historic Places including 4 places of Statewide significance. Significant places include Bynum Mound and Village Site (22CS501), Houston Carnegie Library, Owl Creek Site and Thelma Mound Archaeological Site and Elliott-Donaldson House.
Prehistoric cultural affiliation(s) include Miller I Phase, Mississippian, Miller Ii, Early Mississippian, Transitional Late Woodland and Choctaw dating back to 499 BC. Prominent architectural styles found in Chickasaw Country are Greek Revival, Bungalow/Craftsman and Classical Revival.