Leflore County Mississippi (Historic Districts) has 8 places on the National Register of Historic Places including 1 place of Statewide significance. Significant places include Cotton Row Historic District, Boulevard Subdivision Historic District, Central Commercial and Railroad Historic District, Four Corners Historic District and Itta Bena Historic District.
Some of the country's most noteable architects helped create the Leflore County places including Thomas Henry Jr. Johnson and Frank R. McGeoy. Prominent architectural styles found in Leflore Country are Late 19th And 20th Century Revivals, Queen Anne and Bungalow/Craftsman.