Prehistoric cultural affiliation(s) include Mississippian, Baytown Period, Markville Period, Marksville, Lake Gulf Formational, Mississippian Period, Late Woodland/Deasonville, Late Mississippian, Wasp Lake Phase, Poverty Point, Tchefuncte, Jaketown Phase, Poverty Point Period, Tchula Period, Mcgary Phase, Early Baytown Period, Deasonville-Bayland Phases and Mississippian Phase dating back to 1999 BC.
Several famous people are associated with these Leflore County historic places including William Madison Whittington and C.E. Wright.
Some of the country's most noteable architects helped create the Leflore County places including Jeremiah Simonson, Ben Price, Riley-Bailey Construction Co., Frank R. McGeoy, Eli Jr. Abbott, Reuben Harris Hunt, George Mahon, Henry Sisloff, George Mahan and Thomas Henry Jr. Johnson. Prominent architectural styles found in Leflore Country are Queen Anne, Classical Revival and Late 19th And 20th Century Revivals.