Karnes County Texas has 3 places on the National Register of Historic Places including 1 place of National significance and 2 places of Statewide significance. Significant places include Panna Maria Historic District, Panna Maria Historic District and Ruckman, John, House, Karnes County Courthouse.
Some of the country's most noteable architects helped create the Karnes County places including unknown, Jacob Astor Austin and John Cormach. Prominent architectural styles found in Karnes Country are Gothic Revival, Greek Revival and Romanesque.