Pickaway County Ohio (Historic Districts) has 4 places on the National Register of Historic Places including 2 places of Statewide significance. Significant places include Ohio and Erie Canal Southern Descent Historic District and Tick Ridge Mound District, Circleville Historic District, Fleming-Hoffman Farm.
Prehistoric cultural affiliation(s) include Adena dating back to 499 BC.
Some of the country's most noteable architects helped create the Pickaway County places including Daniel Driesbach. Prominent architectural styles found in Pickaway Country are Late Victorian and Mid 19th Century Revival.