De Soto County Mississippi has 9 places on the National Register of Historic Places including 1 place of Statewide significance. Significant places include Labauve, Felix, House, Dockery House, Hernando Commerce Street Historic District, Hernando Courthouse Square District and Hernando North Side Historic District.
The famous person Felix Labauve is associated with one of more of the De Soto County historic places. Prominent architectural styles found in De Soto Country are Greek Revival, Italianate and Queen Anne.