Prehistoric cultural affiliation(s) include Middle Woodland dating back to 499 BC.
The famous person Wendell L. Wilkie is associated with one of more of the Madison County historic places.
Some of the country's most noteable architects helped create the Madison County places including Charles F. Parker, Miller, Erwin,, Thompson & Millspaugh, John Eberson, Bohn & Mueller Vonnegut, Ernest R. Wakins, Ernest R. Watkins, McCarthy & Bulford Richards, Erwin F. Miiler and A.J. Company Glasser. Prominent architectural styles found in Madison Country are Art Deco, Romanesque and Bungalow/Craftsman.