Prehistoric cultural affiliation(s) include Adena dating back to 499 BC.
The famous person John P. Acton is associated with one of more of the Preble County historic places.
Some of the country's most noteable architects helped create the Preble County places including Evrett S. Sherman, Orlistus Roberts, Joseph Campbell, Columbia Bridge Works, Stephen O. Yeates, Ohio Contractors Oxford, John Zitzer, Lloyd and Hewitt, Sprinkle & Detamore Sanders and Moses Nelson. Prominent architectural styles found in Preble Country are Federal, Greek Revival and Italianate.