Prehistoric cultural affiliation(s) include Late Woodland and Archaic dating back to 1999 BC.
The famous person Joseph Cloyd McGavock is associated with one of more of the Wythe County historic places.
Some of the country's most noteable architects helped create the Wythe County places including Laurence Krone, Lorain Thorn, James Johnson, Morris C. Miller, Graham and Robinson, Wesley Johnson and M Lynch. Prominent architectural styles found in Wythe Country are Greek Revival, Late Victorian and Classical Revival.